AustralieFrV1, Main, Exploration, bibRecord, 000A84

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

Identifieur interne : 000A84 ( Main/Exploration ); précédent : 000A83; suivant : 000A85

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

Auteurs : Emiel P C. Van Der Vorst [Allemagne] ; Kosta Theodorou [Pays-Bas] ; Yongzheng Wu [France] ; Marten A. Hoeksema [Pays-Bas] ; Pieter Goossens [France] ; Christina A. Bursill [Australie] ; Taghi Aliyev [Pays-Bas] ; Leonie F A. Huitema [Pays-Bas] ; Sander W. Tas [Pays-Bas] ; Ine M J. Wolfs [Pays-Bas] ; Marijke J E. Kuijpers [Pays-Bas] ; Marion J. Gijbels [Pays-Bas] ; Casper G. Schalkwijk [Pays-Bas] ; Debby P Y. Koonen [Pays-Bas] ; Shahla Abdollahi-Roodsaz [Pays-Bas] ; Kimberly Mcdaniels [États-Unis] ; Chih-Chieh Wang [États-Unis] ; Michael Leitges [Norvège] ; Toby Lawrence [France] ; Jogchum Plat [Pays-Bas] ; Miranda Van Eck [Pays-Bas] ; Kerry-Anne Rye [Australie] ; Lhousseine Touqui [France] ; Menno P J. De Winther [Pays-Bas] ; Erik A L. Biessen [Allemagne] ; Marjo M P C. Donners [Pays-Bas]

Source :

Cell metabolism [ 1932-7420 ] ; 2017.

RBID : pubmed:27866837

Descripteurs français

English descriptors

KwdEn :
- Animals, Base Sequence, Biological Transport (drug effects), Cells, Cultured, Cholesterol (metabolism), Humans, Inflammation (metabolism), Inflammation (pathology), Interferon Regulatory Factor-1 (metabolism), Lipoproteins, HDL (pharmacology), Macrophages (metabolism), Macrophages (pathology), Membrane Microdomains (drug effects), Membrane Microdomains (metabolism), Mice, Mice, Inbred C57BL, Models, Biological, NF-kappa B (metabolism), Protein Kinase C (metabolism), Respiratory Tract Infections (metabolism), Respiratory Tract Infections (microbiology), Respiratory Tract Infections (pathology), STAT1 Transcription Factor (metabolism), Signal Transduction (drug effects), Toll-Like Receptors (metabolism).
MESH :
- chemical , metabolism : Cholesterol, Interferon Regulatory Factor-1, NF-kappa B, Protein Kinase C, STAT1 Transcription Factor, Toll-Like Receptors.
- drug effects : Biological Transport, Membrane Microdomains, Signal Transduction.
- metabolism : Inflammation, Macrophages, Membrane Microdomains, Respiratory Tract Infections.
- microbiology : Respiratory Tract Infections.
- pathology : Inflammation, Macrophages, Respiratory Tract Infections.
- chemical , pharmacology : Lipoproteins, HDL.
- Animals, Base Sequence, Cells, Cultured, Humans, Mice, Mice, Inbred C57BL, Models, Biological.

Abstract

Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory effects in various cell types, its effects on inflammatory responses in macrophages remain elusive. Here we show overt pro-inflammatory effects of HDL-mediated passive cholesterol depletion and lipid raft disruption in murine and human primary macrophages in vitro. These pro-inflammatory effects were confirmed in vivo in peritoneal macrophages from apoA-I transgenic mice, which have elevated HDL levels. In line with these findings, the innate immune responses required for clearance of P. aeruginosa bacterial infection in lung were compromised in mice with low HDL levels. Expression analysis, ChIP-PCR, and combinatorial pharmacological and genetic intervention studies unveiled that both native and reconstituted HDL enhance Toll-like-receptor-induced signaling by activating a PKC-NF-κB/STAT1-IRF1 axis, leading to increased inflammatory cytokine expression. HDL's pro-inflammatory activity supports proper functioning of macrophage immune responses.

DOI: 10.1016/j.cmet.2016.10.013
PubMed: 27866837

Affiliations:

Le document en format XML

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<orgName type="university">Université de Sydney</orgName>
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<author><name sortKey="Aliyev, Taghi" sort="Aliyev, Taghi" uniqKey="Aliyev T" first="Taghi" last="Aliyev">Taghi Aliyev</name>
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<author><name sortKey="Huitema, Leonie F A" sort="Huitema, Leonie F A" uniqKey="Huitema L" first="Leonie F A" last="Huitema">Leonie F A. Huitema</name>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
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</affiliation>
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<author><name sortKey="Gijbels, Marion J" sort="Gijbels, Marion J" uniqKey="Gijbels M" first="Marion J" last="Gijbels">Marion J. Gijbels</name>
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<author><name sortKey="Schalkwijk, Casper G" sort="Schalkwijk, Casper G" uniqKey="Schalkwijk C" first="Casper G" last="Schalkwijk">Casper G. Schalkwijk</name>
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<wicri:regionArea>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Koonen, Debby P Y" sort="Koonen, Debby P Y" uniqKey="Koonen D" first="Debby P Y" last="Koonen">Debby P Y. Koonen</name>
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<author><name sortKey="Wang, Chih Chieh" sort="Wang, Chih Chieh" uniqKey="Wang C" first="Chih-Chieh" last="Wang">Chih-Chieh Wang</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Leitges, Michael" sort="Leitges, Michael" uniqKey="Leitges M" first="Michael" last="Leitges">Michael Leitges</name>
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</affiliation>
</author>
<author><name sortKey="Lawrence, Toby" sort="Lawrence, Toby" uniqKey="Lawrence T" first="Toby" last="Lawrence">Toby Lawrence</name>
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<country xml:lang="fr">France</country>
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<placeName><settlement type="city">Marseille</settlement>
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</placeName>
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<author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden</wicri:regionArea>
<wicri:noRegion>2333 CC Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<affiliation wicri:level="4"><nlm:affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
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<author><name sortKey="Touqui, Lhousseine" sort="Touqui, Lhousseine" uniqKey="Touqui L" first="Lhousseine" last="Touqui">Lhousseine Touqui</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris</wicri:regionArea>
<wicri:noRegion>75015 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Winther, Menno P J" sort="De Winther, Menno P J" uniqKey="De Winther M" first="Menno P J" last="De Winther">Menno P J. De Winther</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biessen, Erik A L" sort="Biessen, Erik A L" uniqKey="Biessen E" first="Erik A L" last="Biessen">Erik A L. Biessen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
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<author><name sortKey="Donners, Marjo M P C" sort="Donners, Marjo M P C" uniqKey="Donners M" first="Marjo M P C" last="Donners">Marjo M P C. Donners</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands. Electronic address: marjo.donners@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.</title>
<author><name sortKey="Van Der Vorst, Emiel P C" sort="Van Der Vorst, Emiel P C" uniqKey="Van Der Vorst E" first="Emiel P C" last="Van Der Vorst">Emiel P C. Van Der Vorst</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address: e.vandervorst@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
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<author><name sortKey="Theodorou, Kosta" sort="Theodorou, Kosta" uniqKey="Theodorou K" first="Kosta" last="Theodorou">Kosta Theodorou</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yongzheng" sort="Wu, Yongzheng" uniqKey="Wu Y" first="Yongzheng" last="Wu">Yongzheng Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Cellular Biology of Microbial Infection, CNRS UMR3691, Institut Pasteur, 75015 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unit of Cellular Biology of Microbial Infection, CNRS UMR3691, Institut Pasteur, 75015 Paris</wicri:regionArea>
<wicri:noRegion>75015 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoeksema, Marten A" sort="Hoeksema, Marten A" uniqKey="Hoeksema M" first="Marten A" last="Hoeksema">Marten A. Hoeksema</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goossens, Pieter" sort="Goossens, Pieter" uniqKey="Goossens P" first="Pieter" last="Goossens">Pieter Goossens</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille</wicri:regionArea>
<wicri:noRegion>13288 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bursill, Christina A" sort="Bursill, Christina A" uniqKey="Bursill C" first="Christina A" last="Bursill">Christina A. Bursill</name>
<affiliation wicri:level="4"><nlm:affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Aliyev, Taghi" sort="Aliyev, Taghi" uniqKey="Aliyev T" first="Taghi" last="Aliyev">Taghi Aliyev</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huitema, Leonie F A" sort="Huitema, Leonie F A" uniqKey="Huitema L" first="Leonie F A" last="Huitema">Leonie F A. Huitema</name>
<affiliation wicri:level="1"><nlm:affiliation>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tas, Sander W" sort="Tas, Sander W" uniqKey="Tas S" first="Sander W" last="Tas">Sander W. Tas</name>
<affiliation wicri:level="1"><nlm:affiliation>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Amsterdam Rheumatology and Immunology Center, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wolfs, Ine M J" sort="Wolfs, Ine M J" uniqKey="Wolfs I" first="Ine M J" last="Wolfs">Ine M J. Wolfs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kuijpers, Marijke J E" sort="Kuijpers, Marijke J E" uniqKey="Kuijpers M" first="Marijke J E" last="Kuijpers">Marijke J E. Kuijpers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biochemistry, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gijbels, Marion J" sort="Gijbels, Marion J" uniqKey="Gijbels M" first="Marion J" last="Gijbels">Marion J. Gijbels</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schalkwijk, Casper G" sort="Schalkwijk, Casper G" uniqKey="Schalkwijk C" first="Casper G" last="Schalkwijk">Casper G. Schalkwijk</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koonen, Debby P Y" sort="Koonen, Debby P Y" uniqKey="Koonen D" first="Debby P Y" last="Koonen">Debby P Y. Koonen</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abdollahi Roodsaz, Shahla" sort="Abdollahi Roodsaz, Shahla" uniqKey="Abdollahi Roodsaz S" first="Shahla" last="Abdollahi-Roodsaz">Shahla Abdollahi-Roodsaz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Experimental Rheumatology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen</wicri:regionArea>
<wicri:noRegion>6525 GA Nijmegen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcdaniels, Kimberly" sort="Mcdaniels, Kimberly" uniqKey="Mcdaniels K" first="Kimberly" last="Mcdaniels">Kimberly Mcdaniels</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Chih Chieh" sort="Wang, Chih Chieh" uniqKey="Wang C" first="Chih-Chieh" last="Wang">Chih-Chieh Wang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leitges, Michael" sort="Leitges, Michael" uniqKey="Leitges M" first="Michael" last="Leitges">Michael Leitges</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Biotechnology Centre of Oslo, University of Oslo, 0313 Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lawrence, Toby" sort="Lawrence, Toby" uniqKey="Lawrence T" first="Toby" last="Lawrence">Toby Lawrence</name>
<affiliation wicri:level="1"><nlm:affiliation>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, 13288 Marseille</wicri:regionArea>
<wicri:noRegion>13288 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Human Biology, Nutrim, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Division of Biopharmaceutics, Leiden Academic Center for Drug Research, Leiden University, 2333 CC Leiden</wicri:regionArea>
<wicri:noRegion>2333 CC Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<affiliation wicri:level="4"><nlm:affiliation>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Heart Research Institute, 2050 Newtown, Australia; Sydney Medical School, University of Sydney, 2006 Sydney, Australia; Centre for Vascular Research, University of New South Wales, 2052 Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Touqui, Lhousseine" sort="Touqui, Lhousseine" uniqKey="Touqui L" first="Lhousseine" last="Touqui">Lhousseine Touqui</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Infection & Epidemiology, Institut Pasteur, 75015 Paris</wicri:regionArea>
<wicri:noRegion>75015 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Winther, Menno P J" sort="De Winther, Menno P J" uniqKey="De Winther M" first="Menno P J" last="De Winther">Menno P J. De Winther</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Biochemistry, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biessen, Erik A L" sort="Biessen, Erik A L" uniqKey="Biessen E" first="Erik A L" last="Biessen">Erik A L. Biessen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; IMCARIM, Uniklinikum Aachen, 52074 Aachen</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Donners, Marjo M P C" sort="Donners, Marjo M P C" uniqKey="Donners M" first="Marjo M P C" last="Donners">Marjo M P C. Donners</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands. Electronic address: marjo.donners@maastrichtuniversity.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Genetics, CARIM, Maastricht University, 6200 MD Maastricht, the Netherlands; Department of Pathology, CARIM, Maastricht University, 6200 MD Maastricht</wicri:regionArea>
<wicri:noRegion>6200 MD Maastricht</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell metabolism</title>
<idno type="eISSN">1932-7420</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Biological Transport (drug effects)</term>
<term>Cells, Cultured</term>
<term>Cholesterol (metabolism)</term>
<term>Humans</term>
<term>Inflammation (metabolism)</term>
<term>Inflammation (pathology)</term>
<term>Interferon Regulatory Factor-1 (metabolism)</term>
<term>Lipoproteins, HDL (pharmacology)</term>
<term>Macrophages (metabolism)</term>
<term>Macrophages (pathology)</term>
<term>Membrane Microdomains (drug effects)</term>
<term>Membrane Microdomains (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Models, Biological</term>
<term>NF-kappa B (metabolism)</term>
<term>Protein Kinase C (metabolism)</term>
<term>Respiratory Tract Infections (metabolism)</term>
<term>Respiratory Tract Infections (microbiology)</term>
<term>Respiratory Tract Infections (pathology)</term>
<term>STAT1 Transcription Factor (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Toll-Like Receptors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cholestérol (métabolisme)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Facteur de transcription STAT-1 (métabolisme)</term>
<term>Facteur-1 de régulation d'interféron (métabolisme)</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire (anatomopathologie)</term>
<term>Infections de l'appareil respiratoire (microbiologie)</term>
<term>Infections de l'appareil respiratoire (métabolisme)</term>
<term>Inflammation (anatomopathologie)</term>
<term>Inflammation (métabolisme)</term>
<term>Lipoprotéines HDL (pharmacologie)</term>
<term>Macrophages (anatomopathologie)</term>
<term>Macrophages (métabolisme)</term>
<term>Microdomaines membranaires ()</term>
<term>Microdomaines membranaires (métabolisme)</term>
<term>Modèles biologiques</term>
<term>Protéine kinase C (métabolisme)</term>
<term>Récepteurs de type Toll (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal ()</term>
<term>Transport biologique ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term>
<term>Interferon Regulatory Factor-1</term>
<term>NF-kappa B</term>
<term>Protein Kinase C</term>
<term>STAT1 Transcription Factor</term>
<term>Toll-Like Receptors</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
<term>Inflammation</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biological Transport</term>
<term>Membrane Microdomains</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term>
<term>Macrophages</term>
<term>Membrane Microdomains</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Facteur de transcription STAT-1</term>
<term>Facteur-1 de régulation d'interféron</term>
<term>Infections de l'appareil respiratoire</term>
<term>Inflammation</term>
<term>Macrophages</term>
<term>Microdomaines membranaires</term>
<term>Protéine kinase C</term>
<term>Récepteurs de type Toll</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term>
<term>Macrophages</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Lipoprotéines HDL</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipoproteins, HDL</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Base Sequence</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Models, Biological</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Microdomaines membranaires</term>
<term>Modèles biologiques</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Séquence nucléotidique</term>
<term>Transduction du signal</term>
<term>Transport biologique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Membrane cholesterol modulates a variety of cell signaling pathways and functions. While cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory effects in various cell types, its effects on inflammatory responses in macrophages remain elusive. Here we show overt pro-inflammatory effects of HDL-mediated passive cholesterol depletion and lipid raft disruption in murine and human primary macrophages in vitro. These pro-inflammatory effects were confirmed in vivo in peritoneal macrophages from apoA-I transgenic mice, which have elevated HDL levels. In line with these findings, the innate immune responses required for clearance of P. aeruginosa bacterial infection in lung were compromised in mice with low HDL levels. Expression analysis, ChIP-PCR, and combinatorial pharmacological and genetic intervention studies unveiled that both native and reconstituted HDL enhance Toll-like-receptor-induced signaling by activating a PKC-NF-κB/STAT1-IRF1 axis, leading to increased inflammatory cytokine expression. HDL's pro-inflammatory activity supports proper functioning of macrophage immune responses.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Bavière</li>
<li>District de Cologne</li>
<li>District de Haute-Bavière</li>
<li>Groningue (province)</li>
<li>Massachusetts</li>
<li>Nouvelle-Galles du Sud</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement><li>Aix-la-Chapelle</li>
<li>Groningue (ville)</li>
<li>Marseille</li>
<li>Munich</li>
<li>Oslo</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Groningue</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Van Der Vorst, Emiel P C" sort="Van Der Vorst, Emiel P C" uniqKey="Van Der Vorst E" first="Emiel P C" last="Van Der Vorst">Emiel P C. Van Der Vorst</name>
</region>
<name sortKey="Biessen, Erik A L" sort="Biessen, Erik A L" uniqKey="Biessen E" first="Erik A L" last="Biessen">Erik A L. Biessen</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Theodorou, Kosta" sort="Theodorou, Kosta" uniqKey="Theodorou K" first="Kosta" last="Theodorou">Kosta Theodorou</name>
</noRegion>
<name sortKey="Abdollahi Roodsaz, Shahla" sort="Abdollahi Roodsaz, Shahla" uniqKey="Abdollahi Roodsaz S" first="Shahla" last="Abdollahi-Roodsaz">Shahla Abdollahi-Roodsaz</name>
<name sortKey="Aliyev, Taghi" sort="Aliyev, Taghi" uniqKey="Aliyev T" first="Taghi" last="Aliyev">Taghi Aliyev</name>
<name sortKey="De Winther, Menno P J" sort="De Winther, Menno P J" uniqKey="De Winther M" first="Menno P J" last="De Winther">Menno P J. De Winther</name>
<name sortKey="Donners, Marjo M P C" sort="Donners, Marjo M P C" uniqKey="Donners M" first="Marjo M P C" last="Donners">Marjo M P C. Donners</name>
<name sortKey="Gijbels, Marion J" sort="Gijbels, Marion J" uniqKey="Gijbels M" first="Marion J" last="Gijbels">Marion J. Gijbels</name>
<name sortKey="Hoeksema, Marten A" sort="Hoeksema, Marten A" uniqKey="Hoeksema M" first="Marten A" last="Hoeksema">Marten A. Hoeksema</name>
<name sortKey="Huitema, Leonie F A" sort="Huitema, Leonie F A" uniqKey="Huitema L" first="Leonie F A" last="Huitema">Leonie F A. Huitema</name>
<name sortKey="Koonen, Debby P Y" sort="Koonen, Debby P Y" uniqKey="Koonen D" first="Debby P Y" last="Koonen">Debby P Y. Koonen</name>
<name sortKey="Kuijpers, Marijke J E" sort="Kuijpers, Marijke J E" uniqKey="Kuijpers M" first="Marijke J E" last="Kuijpers">Marijke J E. Kuijpers</name>
<name sortKey="Plat, Jogchum" sort="Plat, Jogchum" uniqKey="Plat J" first="Jogchum" last="Plat">Jogchum Plat</name>
<name sortKey="Schalkwijk, Casper G" sort="Schalkwijk, Casper G" uniqKey="Schalkwijk C" first="Casper G" last="Schalkwijk">Casper G. Schalkwijk</name>
<name sortKey="Tas, Sander W" sort="Tas, Sander W" uniqKey="Tas S" first="Sander W" last="Tas">Sander W. Tas</name>
<name sortKey="Van Eck, Miranda" sort="Van Eck, Miranda" uniqKey="Van Eck M" first="Miranda" last="Van Eck">Miranda Van Eck</name>
<name sortKey="Wolfs, Ine M J" sort="Wolfs, Ine M J" uniqKey="Wolfs I" first="Ine M J" last="Wolfs">Ine M J. Wolfs</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Wu, Yongzheng" sort="Wu, Yongzheng" uniqKey="Wu Y" first="Yongzheng" last="Wu">Yongzheng Wu</name>
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<name sortKey="Goossens, Pieter" sort="Goossens, Pieter" uniqKey="Goossens P" first="Pieter" last="Goossens">Pieter Goossens</name>
<name sortKey="Lawrence, Toby" sort="Lawrence, Toby" uniqKey="Lawrence T" first="Toby" last="Lawrence">Toby Lawrence</name>
<name sortKey="Touqui, Lhousseine" sort="Touqui, Lhousseine" uniqKey="Touqui L" first="Lhousseine" last="Touqui">Lhousseine Touqui</name>
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<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Bursill, Christina A" sort="Bursill, Christina A" uniqKey="Bursill C" first="Christina A" last="Bursill">Christina A. Bursill</name>
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<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Mcdaniels, Kimberly" sort="Mcdaniels, Kimberly" uniqKey="Mcdaniels K" first="Kimberly" last="Mcdaniels">Kimberly Mcdaniels</name>
</region>
<name sortKey="Wang, Chih Chieh" sort="Wang, Chih Chieh" uniqKey="Wang C" first="Chih-Chieh" last="Wang">Chih-Chieh Wang</name>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Leitges, Michael" sort="Leitges, Michael" uniqKey="Leitges M" first="Michael" last="Leitges">Michael Leitges</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A84 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A84 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27866837
   |texte=   High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27866837" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

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Descripteurs français

English descriptors

Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
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